Amherst (Massachusetts) [US]May 14 (ANI): In a recent study, an international team of scientists sheds light on how genes may contribute to type 2 diabetes.
The research findings have been published in the journal Nature Genetics.
“Our findings are important as we move towards using genetic scores to weigh a person’s risk of diabetes,” said study co-author Cassandra Spracklen, assistant professor of biostatistics and epidemiology at the UMass Amherst School of Public. Health and Health Sciences.
The meta-analysis by the DIAMANTE (DIabetes Meta-ANalysis of Trans-Ethnic Association Studies) Consortium of 122 different genome-wide association studies (GWAS) was co-led by Andrew Morris, Professor of Statistical Genetics at the University of Manchester, and Professors Mark McCarthy and Anubha Mahajan of the University of Oxford.
“The global prevalence of type 2 diabetes, a life-altering disease, has quadrupled in the past 30 years, affecting approximately 392 million people in 2015,” Morris said.
The research is an important step towards the ultimate goal of identifying new genes and understanding the biology of disease, which has the potential to help scientists develop new treatments.
It is also an important milestone in the development of “genetic risk scores” to identify individuals who are more prone to develop type 2 diabetes, regardless of their population background.
The meta-analysis compared the DNA of nearly 181,000 people with type 2 diabetes against 1.16 million people who did not have the disease. By searching the entire human genome for sets of genetic markers called single nucleotide polymorphisms, or SNPs, genome-wide association studies look for genetic differences between people with and without a disease.
The technique will allow scientists to zoom in on parts of the genome involved in disease risk, helping to pinpoint the genes that cause the disease.
However, the largest genome-wide association studies of type 2 diabetes have historically involved the DNA of people of European descent, which has made limited progress in understanding the disease in other populations.
To address this bias, scientists at the DIAMANTE Consortium have collected the world’s most diverse collection of genetic information about the disease, with nearly 50 percent of individuals from East Asian, African, South Asian and Hispanic populations.
“To date, more than 80 percent of genomic research of this type has been conducted in white populations of European descent, but we know that scores developed exclusively in individuals of one ancestry do not work well in people of other ancestry.” said Spracklen, who helped analyze and coordinate the sharing of data from the East Asian ancestors.
The new paper builds on Spracklen’s previous research on identifying genetic associations with type 2 diabetes in populations of East Asian descent and identifying genetic associations with diabetes-related traits (fasting glucose, fasting insulin, HbA1c) in populations with multiple ancestors.
“Because our research included people from many different parts of the world, we now have a much more complete picture of the ways in which patterns of genetic risk for type 2 diabetes vary between populations,” McCarthy said.
Mahajan added: “We have now identified 117 genes likely to cause type 2 diabetes, 40 of which have not been previously reported. Therefore, we think this is a major step forward in understanding the biology of this disease.” (ANI)
(This is an unedited and auto-generated story from the syndicated news feed, the Laatstely staff may not have changed or edited the content)
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