Digital generated image of COVID-19 vaccine bottle inside pink neon triangle against purple background.

Moderna shot tailored to Omicron subvariants ‘provides good clinical protection’

Moderna’s experimental Omicron booster generates high levels of antibodies that neutralize subvariants BA.4 and BA.5, according to preliminary clinical trial data.

These sub-variants have gained a foothold in the US and Australiaand are already driving a new wave of infections in the UK

The results of Moderna, which have not been peer-reviewed, Building on an announcement earlier this month that people who received the new booster generally made more Omicron-fighting antibodies than when they received a fourth dose of the original vaccine.

Paul Burton, Moderna’s chief medical officer, said the subjects’ antibody levels were high enough to provide “good clinical protection” against BA.4 and BA.5.

“We know that an antibody level of about 400 units … provides very good clinical protection against COVID infection, and certainly against more serious illness, hospitalization and death,” he said.

Of the 437 adults who had the Omicron-specific booster, those who had not yet had COVID generated mean BA.4 and BA.5 neutralizing antibody levels of 727 units after one month.

People who had a previous COVID infection saw a huge jump in BA.4 and BA.5 neutralizing antibodies: more than 2,700 units.

Participants are tracked to see if they eventually get COVID and when.

Paul Griffin, University of Queensland infectious disease physician and clinical microbiologist, said neutralizing antibody responses were a good surrogate for protection, but the most important thing was to see how well the booster worked in the real world.

“Of course it takes more time to collect that data, so this is a useful first step, but then clinical trials will follow that will hopefully show efficacy in humans.”

A two-in-one COVID shot

The updated Moderna booster, called mRNA-1273,214, was developed in January when: Omicron swept Australia

The shot contains instructions in the form of mRNA that allows your body to make spike proteins — spikes the virus uses to infect our cells.

#Moderna #shot #tailored #Omicron #subvariants #good #clinical #protection

Leave a Comment

Your email address will not be published. Required fields are marked *