According to a University of Florida study, newly identified genes may explain why women have different heart disease symptoms than men, often leading to the misdiagnosis of serious problems. According to Jennifer Dungan, an associate professor at the University of Florida College of Nursing, many of the current symptom profiles and lab tests for heart disease do not accurately reflect the known differences in heart disease in women. This oversight has led to wider gaps in health care equity.
“Because of this disparity, women are more likely than men to report heart disease symptoms that seem out of the norm, experience delayed treatment for heart disease, and even have undiagnosed heart attacks,” Dungan said. “For unclear reasons, women may experience heart disease differently than men. This could lead to inequalities for women that need to be addressed.” Dungan said heart researchers believe some of these differences in symptoms and outcomes may be due to genetic variation between men and women. She has identified a specific gene that she believes is responsible, called RAP1GAP2.”
RAP1GAP2 is a strong candidate for sex-linked effects on cardiovascular disease outcomes in women,” Dungan said. This also puts you at risk of heart attack. An overactive gene can cause too many platelets to respond to the clot, which could block the flow of blood and oxygen to the heart muscle and lead to a heart attack.” Since RAP1GAP2 was not linked to poor heart outcomes in men in her team’s study, she believes this gene may work differently in women. Her team included faculties from UF’s colleges of Medicine, Pharmacy, and Public Health and Health Professions. Their findings are recently published in American Heart Journal Plus.
Even less is known about such differences between races and ethnicities. Black women and some Hispanic women are at even greater risk for poor heart disease outcomes, due to many factors that Dungan believes may include genetics. Unfortunately, the traditional ways in which racial and ethnic groups are studied tend to produce results that are irrelevant, Dungan said.
“The goal is not to find biological differences between groups of people. Our goal is instead to find the gene markers most accurately linked to heart disease for all women,” she said. “And to do that, we also need to account for genetic variation in women.” To discover how the gene may influence cardiovascular disease risk in women of diverse backgrounds, Dungan’s latest project, supported by a two-year grant from the National Institute on Aging, a division of the National Institutes of Health, has reached aim to find the specific RAP1GAP2 gene. markers that correlate most strongly with disease symptoms, heart attacks and death in women of different racial and ethnic groups.
Using health data from 17,000 postmenopausal women, Dungan and her team will use statistical genetic methods to analyze whether there is a link between certain DNA markers on RAP1GAP2 and heart disease. Her team will also use genetic ancestry markers rather than random racial categories to account for natural diversity in our genetic code. According to Dungan, this will help her team find gene markers that reflect all cardiovascular disease risks in women, not just certain groups. “By the end of the study, if RAP1GAP2 gene markers accurately reflect women’s heart symptoms and predict their likelihood of a future heart attack, stroke or death, those gene markers could help us feel more confident about their diagnosis and future prognosis,” she said. . said. “Having more accurate biomarkers for women would save lives and improve health equity for all women.” (ANI)
(This story has not been edited by Devdiscourse staff and is automatically generated from a syndicated feed.)
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